The Basophilic Granulocyte

The basophilic granulocyte.

Shuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity

BACKGROUND Basophilic granulocytes (BGs) not only initiate the induction of Th2 cell differentiation, but also amplify the ongoing Th2 response. Shuang-Huang-Lian (SHL) is clinically used for relieving type I hypersensitivity by continuous treatment for several weeks. METHODS ELISA, flow cytometry, magnetic activated cell sorting, isoelectric precipitation, hybridoma technique, transfection a...

basophilic leukaemia cells

Rat annexin II cDNA clones were isolated from a rat basophilic leukaemia cell plasmid library by cross-species hybridization with a mouse probe, and fully sequenced using the dideoxychain-termination method. Alignment of the derived amino-acid sequence with those of other mammalian annexin II species revealed a high level ofconservation, characteristic ofthe annexin family of proteins. One of t...

Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation.

We have recently shown that nerve growth factor (NGF) promotes human granulopoiesis, specifically augmenting basophilic cell differentiation observed in methylcellulose hematopoietic colony assays of human peripheral blood. Because the NGF effect was seen in the presence of conditioned medium derived from a human T-cell line (Mo-CM) containing granulocyte-macrophage colony-stimulating factor (G...

Circulating basophilic leucocyte counts in the newborn.

Recent evidence that histamine is present in basophilic kucocytes (Graham, Wheelwright, Parish, Marks and Lowry, 1952; Code and Mitchell, 1954) as well as in tissue mast cells (Riley and West, 1953) has created fresh interest in these cells. Knowledge of variations in the number of crulating basophils is scanty owing to the inaccuracy of smear techniques, but the introduction of a chamber-count...